A trial design that generates only ′′positive′′ results
نویسندگان
چکیده
منابع مشابه
A trial design that generates only ''positive'' results.
In this article, we test the hypothesis that randomized clinical trials of acupuncture for pain with certain design features (A + B versus B) are likely to generate false positive results. Based on electronic searches in six databases, 13 studies were found that met our inclusion criteria. They all suggested that acupuncture is effected (one only showing a positive trend, all others had signifi...
متن کاملDesign of Genetic Switches with Only Positive Feedback Loops
We develop a new methodology to design synthetic genetic switch networks with multiple genes and time delays, by using monotone dynamical theory. We show that the networks with only positive feedback loops have no stable oscillation except equilibria whose stability is also independent of the time delays. Such systems have ideal properties for switch networks and can be designed with out consid...
متن کاملPositive results for mechanism design without money
Consider the problem of allocating multiple divisible goods to two agents in a strategy-proof fashion without the use of payments or priors. Previous work [1, 2] has aimed at implementing allocations that are competitive with respect to an appropriately defined measure of social welfare. These results have mostly been negative, proving that no dictatorial mechanism can achieve an approximation ...
متن کاملMultiple hypothesis testing to detect lineages under positive selection that affects only a few sites.
Detection of positive Darwinian selection has become ever more important with the rapid growth of genomic data sets. Recent branch-site models of codon substitution account for variation of selective pressure over branches on the tree and across sites in the sequence and provide a means to detect short episodes of molecular adaptation affecting just a few sites. In likelihood ratio tests based ...
متن کاملDo certain countries produce only positive results? A systematic review of controlled trials.
OBJECTIVE To determine whether clinical trials originating in certain countries always have positive results. DATA SOURCES Abstracts of trials from Medline (January 1966-June 1995). STUDY SELECTION Two separate studies were conducted. The first included trials in which the clinical outcome of a group of subjects receiving acupuncture was compared to that of a group receiving placebo, no tre...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Postgraduate Medicine
سال: 2008
ISSN: 0022-3859
DOI: 10.4103/0022-3859.41806